<ArticleSet>
<Article>
<Journal>
<PublisherName>Trauma Research Center</PublisherName>
<JournalTitle>Bulletin of Emergency And Trauma</JournalTitle>
<Issn>2322-2522</Issn>
<Volume>5</Volume>
<Issue>3 JUL</Issue>
<PubDate>
<Year>2017</Year>
<Month>07</Month>
<Day>01</Day>
</PubDate>
</Journal>
<ArticleTitle>Functional, Histopathological and Immunohistichemical Assessments of Cyclosporine A on Sciatic Nerve Regeneration Using Allografts: A Rat Sciatic Nerve Model</ArticleTitle>
<FirstPage>381</FirstPage>
<LastPage>381</LastPage>
<Language>EN</Language>
<AuthorList>
<Author>
<FirstName>Amir</FirstName>
<LastName>Amniattalab</LastName>
<Affiliation>Young Researchers and Elite Club, Urmia Branch, Islamic Azad University, Urmia, Iran. a.amniattalab@iaurmia.ac.ir</Affiliation>
</Author>
<Author>
<FirstName>Rahim</FirstName>
<LastName>Mohammadi</LastName>
</Author>
</AuthorList>
<History>
<PubDate>
<Year>2016</Year>
<Month>12</Month>
<Day>11</Day>
</PubDate>
<PubDate>
<Year>2017</Year>
<Month>04</Month>
<Day>27</Day>
</PubDate>
<PubDate>
<Year>2017</Year>
<Month>04</Month>
<Day>25</Day>
</PubDate>
</History>
<Abstract>Objectives: To study the functional, histopathological and immunohistochemical effect of cyclosporine A on sciatic nerve regeneration using allografts in a rat sciatic nerve model.Methods: Thirty male white Wistar rats were divided into three experimental groups (n = 10), randomly: Normal control group (NC), allograft group (ALLO), CsA treated group (ALLO/ CsA). In NC group left sciatic nerve was exposed through a gluteal muscle incision and after homeostasis muscle was sutured. In the ALLO group the left sciatic nerve was exposed through a gluteal muscle incision and transected proximal to the tibio-peroneal bifurcation where a 10 mm segment was excised. The same procedure was performed in the ALLO/ CsA group and the animals were treated with interaperitoneal administration of cyclosporine A. The harvested nerves of the rats of ALLO group were served as allograft for ALLO/ CsA group and vice versa. The NC and ALLO groups received 300 μL sterile olive oil interaperitoneally once a day for one week and the ALLO/ CsA group received 300 μL CsA (1mg/kg/day) interaperitoneally once a day for one week.Results: Behavioral, functional, biomechanical and gastrocnemius muscle mass showed earlier regeneration of axons in ALLO/ CsA than in ALLO group (p=0.001). Histomorphometic and immunohistochemical studies also showed earlier regeneration of axons in ALLO/ CsA than in ALLO group (p=0.034).Conclusion: Administration of CsA could accelerate functional recovery after nerve allografting in sciatic nerve. It may have clinical implications for the surgical management of patients after nerve transection in emergency conditions.</Abstract>
<ObjectList>
<Object>
<Param>Peripheral nerve repair</Param>
</Object>
<Object>
<Param>Sciatic</Param>
</Object>
<Object>
<Param>Cyclosporine A</Param>
</Object>
<Object>
<Param>Allograft.</Param>
</Object>
</ObjectList>
</Article>
</ArticleSet>